U.S. Department of Agriculture: Animal and Plant Health Inspection Service

 

United States Department of Agriculture Wildlife Services: Staff Publications

Document Type

Article

Date of this Version

2017

Citation

Scientific Reports, 6:33430, DOI: 10.1038/srep33430

Comments

This work is licensed under a Creative Commons Attribution 4.0 International License

Abstract

Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates. Among dams using weighted UniFrac distances, TCC induced significant dysbiosis of gut microbiota by gestational day (GD) 18, a trend that continued after delivery. Similarly, an overall restructuring of gut microbiota occurred in neonates. By postnatal day (PND) 12, communities separated based on exposure status and became significantly different at PND 16. The ability of TCC to drive microbial dysbiosis warrants future investigation to evaluate the safety of nonprescription antimicrobial use, including TCC, during critical exposure windows.

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