Date of this Version
Lin and Gu, J Biosens Bioelectron 2016, 7:1
The extracellular matrix (ECM) is essential for regulating cell behavior and tissue function . Local ECM structure and mechanics are increasingly recognized as important mechanical effectors of cell responses and tissue regeneration . This is illustrated by the fact that either the rigidity of ECM  or local tension regulate cellular mechanotransduction pathways, and their dysregulation results in many different types of diseases [4,5]. It was speculated that cell contractions, generated by the cross-bridging interaction of actin and myosin II motors, maintain a tensional homeostasis in response to mechanical disturbance. The question is what is exactly the tensional homeostasis, if any?