Parasitology, Harold W. Manter Laboratory of
Date of this Version
4-1977
Abstract
Sporulated oocysts of Eimeria nieschulzi Dieben 1924, a rat coccidium, were exposed to radiation, heat, or both in an effort to attenuate the parasite. Moderate levels of each treatment or combination thereof attenuated the parasite, reduced pathogenesis (as judged by oocyst discharge during primary infection), and produced immunity to challenge when the oocysts were subsequently inoculated into rats. Thus, heat- and/or radiation-treated E. nieschulzi oocysts fed to rats could reduce pathogenesis during a primary infection and yet give good homologous protection.
Comments
Published in the Journal of Parasitology (April 1977) 63(2): 206-209. Copyright 1977, the American Society of Parasitologists. Used by permission.