Escherichia coli O157:H7 Requires Intimin for Enteropathogenicity in Calves

Authors

Evelyn A. Dean-Nystrom, Pre-Harvest Food Safety and Enteric Diseases Research UnitFollow
Brad T. Bosworth, United States Department of Agriculture
Harley W. Moon, Iowa State UniversityFollow
Alison D. O’brien, F. Edward Hebert School of Medicine

Document Type

Article

Date of this Version

9-1998

Citation

Infection And Immunity, 66(9): Sept. 1998, P. 4560–4563

Abstract

Enterohemorrhagic Escherichia coli (EHEC) strains require intimin to induce attaching and effacing (A/E) lesions in newborn piglets. Infection of newborn calves with intimin-positive or intimin-negative EHEC O157: H7 demonstrated that intimin is needed for colonization, A/E lesions, and disease in cattle. These results suggest that experiments to determine if intimin-based vaccines reduce O157:H7 levels in cattle are warranted.