Identification of bla_OXA-51-like, bla_OXA-58, bla_DIM-1, and bla_VIM Carbapenemase Genes in Hospital Enterobacteriaceae Isolates from Sierra Leone

Authors

Tomasz A. Leski, Naval Research Laboratory
Umaru Bangura, Mercy Hospital Research Laboratory
David H. Jimmy, Mercy Hospital Research Laboratory
Rashid Ansumana, Naval Research Laboratory
Stephen E. Lizewski, Naval Research Laboratory
Robert W. Li, Animal and Natural Resources Institute
David A. Stenger, Naval Research Laboratory
Chris R. Taitt, Naval Research Laboratory
Gary J. Vora, Naval Research LaboratoryFollow

Date of this Version

2013

Citation

Published in Journal of Clinical Microbiology (July 2013) 51:7, p. 2435-2438. DOI:10.1128/JCM.00832-13

Abstract

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the bla_DIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) bla_OXA-51-like and bla_OXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.