Identification of bla_OXA-51-like, bla_OXA-58, bla_DIM-1, and bla_VIM Carbapenemase Genes in Hospital Enterobacteriaceae Isolates from Sierra Leone

Authors

• Tomasz A. Leski, Naval Research Laboratory
• Umaru Bangura, Mercy Hospital Research Laboratory
• David H. Jimmy, Mercy Hospital Research Laboratory
• Rashid Ansumana, Naval Research Laboratory
• Stephen E. Lizewski, Naval Research Laboratory
• Robert W. Li, Animal and Natural Resources Institute
• David A. Stenger, Naval Research Laboratory
• Chris R. Taitt, Naval Research Laboratory
• Gary J. Vora, Naval Research LaboratoryFollow

Date of this Version

2013

Citation

Published in Journal of Clinical Microbiology (July 2013) 51:7, p. 2435-2438. DOI:10.1128/JCM.00832-13

Abstract

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the bla_DIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) bla_OXA-51-like and bla_OXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.