Veterinary and Biomedical Sciences, Department of
Document Type
Article
Date of this Version
2016
Citation
Published in Current Opinion in Virology 16 (2016), pp. 8–14 (issue on viral immunology, edited by Allan J Zajac and Liisa K Selin); doi: 10.1016/j.coviro.2015.10.004
Abstract
Enteroviruses are small, non-enveloped, positive-sense singlestrand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler’s virus infection is the first demonstration of this autoimmune mechanism.
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Comments
Copyright © 2015 Elsevier B.V. Used by permission.