Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Authors

• Caitlin O McAtee, University of Nebraska - Lincoln
• Abigail R. Berkebile, University of Nebraska-Lincoln
• Christian Elowsky, University of Nebraska-LincolnFollow
• Teresa Fangman, University of Nebraska-Lincoln
• Joseph J. Barycki, University of Nebraska - LincolnFollow
• James K. Wahl III, University of Nebraska Medical Center
• Oleh Khalimonchuk, University of Nebraska-LincolnFollow
• Naava Naslavsky, University of Nebraska Medical Center
• Steve Caplan, Fred and Pamela Buffett Cancer Center, Omaha
• Melanie A. Simpson, University of Nebraska- LincolnFollow

ORCID IDs

Christian Elowsky

Document Type

Article

Date of this Version

2015

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 21, pp. 13144–13156, May 22, 2015

Comments

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: Hyal1 is a turnover enzyme for hyaluronan that accelerates metastatic cancer by increasing cell motility.

Results: Hyal1-overexpressing cells have a higher rate of endocytosis that impacts cargo internalization and recycling.

Conclusion: The higher rate of vesicle trafficking increases motility receptor function and nutrient uptake.

Significance: This novel mechanism implicates Hyal1 trafficking in multiple signaling events during tumor progression.