Date of this Version
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 43, pp. 29836–29858, October 24, 2014
Background: Heme oxygenase, cytochrome P450 reductase, and biliverdin reductase are the key enzymes in heme degradation.
Results: Specific electrostatic and hydrophobic interactions form the binding interface between heme oxygenase and cytochrome P450 reductase. Conclusion: Heme oxygenase binds cytochrome P450 reductase dynamically and biliverdin reductase very weakly.
Significance: Characterizing interactions among proteins involved in heme degradation are crucial to understanding heme homeostasis.