Biochemistry, Department of
Date of this Version
2003
Citation
Microbiology And Molecular Biology Reviews, Sept. 2003, p. 454–472 Vol. 67, No. 3
Abstract
INTRODUCTION......................................................................................................................................................454
FATTY ACIDS AND BIOLOGICAL MEMBRANES.............................................................................................455
Fatty Acid Transport Defined ...............................................................................................................................456
MODEL SYSTEMS TO INVESTIGATE FATTY ACID TRANSPORT ..............................................................456
Genetic Foundations of Fatty Acid Transport....................................................................................................456
PROTEINS IMPLICATED IN FATTY ACID TRANSPORT ...............................................................................456
Fatty Acid Translocase..........................................................................................................................................457
Fatty Acid Binding Protein—Membrane Bound ................................................................................................457
Fatty Acid Transport Protein...............................................................................................................................458
The Long-Chain Fatty Acid Transport Protein FadL .......................................................................................458
Fatty Acyl-CoA Synthetase ...................................................................................................................................459
VECTORIAL ACYLATION: ONE MECHANISM OPERATIONAL IN FATTY ACID TRANSPORT...........460
THE BACTERIAL PARADIGM ...............................................................................................................................460
Energetics of Fatty Acid Transport in Gram-Negative Bacteria......................................................................460
The Fatty Acid Transporter FadL........................................................................................................................461
The Fatty Acyl-CoA Synthetase FadD..................................................................................................................461
Structural Considerations of FACS .....................................................................................................................462
FATTY ACID TRANSPORT AND ACTIVATION IN YEAST: EVIDENCE FOR A MULTICOMPONENT
COMPLEX..........................................................................................................................................................463
Role of Fat1p ..........................................................................................................................................................464
Directed Mutagenesis of FAT1 and Functional Organization of Fat1p..........................................................464
The Fatty Acyl-CoA Synthetases Faa1p and Faa4p...........................................................................................465
Interaction of Fat1p and FACS ............................................................................................................................465
FATTY ACID TRANSPORT AND BIOLOGICAL MEMBRANES .....................................................................466
Long-Chain Fatty Acid Transport and Activation in Bacteria: Implications in Early States of
Infection ..............................................................................................................................................................466
Fatty Acid Transport and Trafficking in Yeast ..................................................................................................468
Lessons Applied to Mammalian Systems............................................................................................................469
ACKNOWLEDGMENTS ..........................................................................................................................................469
REFERENCES ...........................................................................................................................................................469
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