Biochemistry, Department of
Date of this Version
10-12-2007
Abstract
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ~120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Gladyshev SCIENCE 2008 Chlamyd Suppl table 1.xls
Gladyshev SCIENCE 2008 Chlamyd Suppl table 2.xls (144 kB)
Gladyshev SCIENCE 2008 Chlamyd Suppl table 2.xls
Comments
Published in SCIENCE VOL 318 12 OCTOBER 2007. Copyright 2007. Used by permission.