TLR-TRIF Pathway Enhances the Expression of KSHV Replication and Transcription Activator

Authors

Florencia Meyer, University of Nebraska-LincolnFollow
Erica Ehlers, University of Nebraska-Lincoln
Andrew Steadman, University of Nebraska-Lincoln
Thomas Waterbury, University of Nebraska-Lincoln
Mingxia Cao, University of Nebraska-Lincoln
Luwen Zhang, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2013

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 28, pp. 20435–20442, July 12, 2013

Comments

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: Host innate immunity is against virus infection and replication.

Results: Toll-like receptor 3 activation leads to enhanced expression of a key Kaposi’s sarcoma-associated herpesvirus (KSHV) protein.

Conclusion: KSHV uses host Toll-like receptor pathway to augment its critical gene expression. Significance: A virus may usurp host innate immunity for its own benefits.