An Assembly of Proteins and Lipid Domains Regulates Transport of Phosphatidylserine to Phosphatidylserine Decarboxylase 2 in Saccharomyces cerevisiae

Authors

• Wayne R. Riekhof, National Jewish Health, Denver, ColoradoFollow
• Wen-I Wu, National Jewish Health, Denver, Colorado
• Jennifer L. Jones, National Jewish Health, Denver, Colorado
• Mrinalini Nikrad, National Jewish Health, Denver, Colorado
• Mallory M. Chan, National Jewish Health, Denver, Colorado
• Christopher J. R. Loewen, University of British Columbia
• Dennis R. Voelker, National Jewish Health, Denver, Colorado

Document Type

Article

Date of this Version

2014

Citation

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 9, pp. 5809–5819, February 28, 2014

Comments

© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Abstract

Background: The machinery for interorganelle phosphatidylserine (PtdSer) transport is poorly defined at the molecular level.

Results: Molecular interaction studies identify specific protein-protein and protein-lipid interactions in PtdSer transport.

Conclusion: A protein and lipid interaction network defines key participants in PS transport to the locus of PtdSer-decarboxylase 2.

Significance: This study identifies important molecular participants involved in non-vesicular phospholipid traffic.