A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase

Authors

Yang Deng, Yale University School of Medicine
Brian A. Couch, Yale UniversityFollow
Anthony J. Koleske, Yale University
Benjamin E. Turk, Yale University School of MedicineFollow

Document Type

Article

Date of this Version

2012

Citation

Chembiochem. 2012 November 26; 13(17): 2510–2512.

Comments

Copyright 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

doi:10.1002/cbic.201200560

Abstract

The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.