Time Domains of Hypoxia Responses and -Omics Insights

Authors

• James J. Yu, Department of Medicine
• Amy L. Non, Division of Social SciencesFollow
• Erica C. Heinrich, UCR School of Medicine
• Wanjun Gu, Department of Medicine
• Joe Alcock, The University of New Mexico
• Esteban A. Moya, Department of Medicine
• Elijah S. Lawrence, Department of Medicine
• Michael S. Tift, University of North Carolina Wilmington
• Katie A. O'Brien, Department of Medicine
• Jay F. Storz, University of Nebraska - LincolnFollow
• Anthony V. Signore, University of Nebraska-Lincoln
• Jane I. Khudyakov, University of the Pacific, California
• William K. Milsom
• Sean M. Wilson, Lawrence D. Longo
• Cynthia M. Beall
• Francisco C. Villafuerte, Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
• Tsering Stobdan
• Colleen G. Julian, University of Colorado School of Medicine
• Lorna G. Moore, Division of Reproductive Sciences
• Mark M. Fuster, Department of Medicine
• Jennifer A. Stokes, Southwestern University
• Richard Milner, San Diego Biomedical Research Institute
• John B. West, Department of Medicine
• Jiao Zhang, Department of Medicine
• John Y. Shyy, Department of Medicine
• Ainash Childebayeva, Max-Planck-Institut für evolutionäre Anthropologie
• José Pablo Vázquez-Medina, University of California, Berkeley
• Luu V. Pham, Johns Hopkins School of Medicine
• Omar A. Mesarwi, Department of Medicine
• James E. Hall, Department of Medicine
• Zachary A. Cheviron, University of Montana
• Jeremy Sieker, Department of Medicine
• Arlin B. Blood, Loma Linda University School of Medicine
• Jason X. Yuan, Department of Medicine
• Tatum S. Simonson, University of California - San DiegoFollow
• et al.

Document Type

Article

Date of this Version

8-8-2022

Citation

Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O’Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL and Simonson TS (2022) Time Domains of Hypoxia Responses and -Omics Insights. Front. Physiol. 13:885295. doi: 10.3389/fphys.2022.885295

Comments

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Abstract

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.