Papers in the Biological Sciences



James J. Yu, Department of Medicine
Amy L. Non, Division of Social SciencesFollow
Erica C. Heinrich, UCR School of Medicine
Wanjun Gu, Department of Medicine
Joe Alcock, The University of New Mexico
Esteban A. Moya, Department of Medicine
Elijah S. Lawrence, Department of Medicine
Michael S. Tift, University of North Carolina Wilmington
Katie A. O'Brien, Department of Medicine
Jay F. Storz, University of Nebraska - LincolnFollow
Anthony V. Signore, University of Nebraska-Lincoln
Jane I. Khudyakov, University of the Pacific, California
William K. Milsom
Sean M. Wilson, Lawrence D. Longo
Cynthia M. Beall
Francisco C. Villafuerte, Laboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno
Tsering Stobdan
Colleen G. Julian, University of Colorado School of Medicine
Lorna G. Moore, Division of Reproductive Sciences
Mark M. Fuster, Department of Medicine
Jennifer A. Stokes, Southwestern University
Richard Milner, San Diego Biomedical Research Institute
John B. West, Department of Medicine
Jiao Zhang, Department of Medicine
John Y. Shyy, Department of Medicine
Ainash Childebayeva, Max-Planck-Institut für evolutionäre Anthropologie
José Pablo Vázquez-Medina, University of California, Berkeley
Luu V. Pham, Johns Hopkins School of Medicine
Omar A. Mesarwi, Department of Medicine
James E. Hall, Department of Medicine
Zachary A. Cheviron, University of Montana
Jeremy Sieker, Department of Medicine
Arlin B. Blood, Loma Linda University School of Medicine
Jason X. Yuan, Department of Medicine
Tatum S. Simonson, University of California - San DiegoFollow
et al.

Date of this Version



Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O’Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL and Simonson TS (2022) Time Domains of Hypoxia Responses and -Omics Insights. Front. Physiol. 13:885295. doi: 10.3389/fphys.2022.885295


This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).


The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.

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