Farnesol Concentrations Required To Block Germ Tube Formation in Candida albicans in the Presence and Absence of Serum

Authors

• Daniel D. Mosel, University of Nebraska-Lincoln
• Raluca Dumitru, University of Nebraska-Lincoln
• Jacob M. Hornby, University of Nebraska-LincolnFollow
• Audrey L. Atkin, University of Nebraska-LincolnFollow
• Kenneth W. Nickerson, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

8-1-2005

Comments

Published in APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Aug. 2005, p. 4938–4940 Vol. 71, No. 8. Copyright © 2005, American Society for Microbiology. All Rights Reserved. Used by permission.

Abstract

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.