Papers in the Biological Sciences
Papers in Microbiology
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Document Type
Article
Date of this Version
6-1-2004
Abstract
The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.
Comments
Published in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 2004, p. 2305–2307 Vol. 48, No. 6. Copyright © 2004, American Society for Microbiology. Used by permission.