Papers in the Biological Sciences


Date of this Version

March 1984


Published in Science, New Series, Vol. 223, No. 4641. (Mar. 16, 1984), pp. 1191–1193. Published by the American Association for the Advancement of Science. Used by permission.


Solubilized crystals of Bacillus thuringiensis var. israelensis were 7,000 times less toxic to Aedes aegypti larvae than intact crystals, presumably because mosquito larvae are filter feeders and selectively concentrate particles while excluding water and soluble molecules. A procedure is described whereby soluble toxins are adsorbed to 0.8- micrometer latex beads, with retention of toxicity. The latex bead assay should make it possible to analyze the structure and mode of action of the mosquito toxin.

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