Potential Roles of Follicular Dendritic Cell–Associated Osteopontin in Lymphoid Follicle Pathology and Repair and in B Cell Regulation in HIV-1 and SIV Infection

Authors

Qingsheng Li, University of Nebraska-LincolnFollow
Jeffrey D. Lifson, National Cancer InstituteFollow
Lijie Duan, University of Minnesota, MinneapolisFollow
Timothy Schacker, University of Minnesota, MinneapolisFollow
Cavan Reilly, University of Minnesota, MinneapolisFollow
John V. Carlis, University of Minnesota, MinneapolisFollow
Jacob D. Estes, University of Minnesota, MinneapolisFollow
Ashley T. Haase, University of MinnesotaFollow

Date of this Version

2005

Document Type

Article

Citation

Published in Journal of Infectious Diseases 192 (2005), pp. 1269–1276.

Comments

Copyright © 2005 Infectious Diseases Society of America; published by Oxford. Used by permission.

Abstract

Osteopontin is a multifunctional protein with known roles in bone remodeling, wound healing, and normal and pathological immune responses. We showed in microarray studies that osteopontin gene expression is increased in human immunodeficiency virus type 1 (HIV-1)–infected lymphatic tissues after treatment, and we undertook mapping experiments to study osteopontin’s possible functions in this context. We discovered species-specific colocalization of osteopontin with the follicular dendritic cell (FDC) network in lymphatic tissues in HIV-1 and simian immunodeficiency virus infections, and we found that changes in FDC-associated osteopontin covary with changes in lymphoid follicles during acute and late stages of infection and in response to treatment. We propose that this localization normally facilitates antibody production and plays a role in B cell abnormalities in infection and in the reconstitution of lymphoid follicles with treatment and that mapping genes identified in microarray studies is a useful experimental approach to gaining a better understanding of function in the context of a particular tissue and disease.