AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Authors

• Anapatricia Garcίa, Yerkes National Primate Research Center, Emory UniversityFollow
• Nagadenahalli B. Siddappa, Dana-Farber Cancer Institute; Harvard Medical School
• Qingsheng Li, University of MinnesotaFollow
• Ashley T. Haase, University of MinnesotaFollow
• Katherine Paul, Centers for Disease Control and Prevention
• Fawn Stroud, Yerkes National Primate Research Center, Emory University
• Xiaodong Zhang, Yerkes National Primate Research Center, Emory University
• Jack A. Fountain, Emory University
• François Villinger, Yerkes National Primate Research Center, Emory University
• Francis J. Novembre, Yerkes National Primate Research Center, Emory University
• James G. Else, Yerkes National Primate Research Center, Emory University
• W. Evan Secor, Centers for Disease Control and Prevention
• Ruth M. Ruprecht, Dana-Farber Cancer Institute; Harvard Medical School

Document Type

Article

Date of this Version

3-21-2010

Citation

J Med Primatol 39 (2010) 356–360; doi:10.1111/j.1600-0684.2010.00416.x

Comments

U.S. Government work

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4⁺ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.