AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Authors

Anapatricia Garcίa, Yerkes National Primate Research Center, Emory UniversityFollow
Nagadenahalli B. Siddappa, Dana-Farber Cancer Institute; Harvard Medical School
Qingsheng Li, University of MinnesotaFollow
Ashley T. Haase, University of MinnesotaFollow
Katherine Paul, Centers for Disease Control and Prevention
Fawn Stroud, Yerkes National Primate Research Center, Emory University
Xiaodong Zhang, Yerkes National Primate Research Center, Emory University
Jack A. Fountain, Emory University
François Villinger, Yerkes National Primate Research Center, Emory University
Francis J. Novembre, Yerkes National Primate Research Center, Emory University
James G. Else, Yerkes National Primate Research Center, Emory University
W. Evan Secor, Centers for Disease Control and Prevention
Ruth M. Ruprecht, Dana-Farber Cancer Institute; Harvard Medical School

Date of this Version

3-21-2010

Document Type

Article

Citation

J Med Primatol 39 (2010) 356–360; doi:10.1111/j.1600-0684.2010.00416.x

Comments

U.S. Government work

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4⁺ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.