Biotechnology, Center for
Document Type
Article
Date of this Version
2011
Citation
International Journal of Nanomedicine 2011:6 3393–3404
Abstract
Nanoformulations of crystalline indinavir, ritonavir, atazanavir, and efavirenz were manufactured by wet milling, homogenization or sonication with a variety of excipients. The chemical, biological, immune, virological, and toxicological properties of these formulations were compared using an established monocyte-derived macrophage scoring indicator system. Measurements of drug uptake, retention, release, and antiretroviral activity demonstrated differences amongst preparation methods. Interestingly, for drug cell targeting and antiretroviral responses the most significant difference among the particles was the drug itself. We posit that the choice of drug and formulation composition may ultimately affect clinical utility.
Comments
© 2011 Balkundi et al
Open access
http://dx.doi.org/10.2147/IJN.S27830