Neural Processing of Emotional Musical and Nonmusical Stimuli in Depression

Authors

Rebecca J. Lepping, University of Kansas Medical CenterFollow
Ruth Ann Atchley, University of Kansas
Evangelia Chrysikou, University of Kansas
Laura E. Martin, University of Kansas Medical CenterFollow
Alicia A. Clair, University of Kansas
Rick E. Ingram, University of Kansas
W. Kyle Simmons, Laureate Institute for Brain Research
Cary R. Savage, University of Nebraska - LincolnFollow

Date of this Version

2016

Document Type

Article

Citation

PLoS ONE 11(6): e0156859.

Comments

© 2016 Lepping et al.

Open access

doi:10.1371/journal.pone.0156859

Abstract

Background Anterior cingulate cortex (ACC) and striatum are part of the emotional neural circuitry implicated in major depressive disorder (MDD). Music is often used for emotion regulation, and pleasurable music listening activates the dopaminergic system in the brain, including the ACC. The present study uses functional MRI (fMRI) and an emotional nonmusical and musical stimuli paradigm to examine how neural processing of emotionally provocative auditory stimuli is altered within the ACC and striatum in depression.

Method Nineteen MDD and 20 never-depressed (ND) control participants listened to standardized positive and negative emotional musical and nonmusical stimuli during fMRI scanning and gave subjective ratings of valence and arousal following scanning.

Results ND participants exhibited greater activation to positive versus negative stimuli in ventral ACC. When compared with ND participants, MDD participants showed a different pattern of activation in ACC. In the rostral part of the ACC, ND participants showed greater activation for positive information, while MDD participants showed greater activation to negative information. In dorsal ACC, the pattern of activation distinguished between the types of stimuli, with ND participants showing greater activation to music compared to nonmusical stimuli, while MDD participants showed greater activation to nonmusical stimuli, with the greatest response to negative nonmusical stimuli. No group differences were found in striatum.

Conclusions These results suggest that people with depression may process emotional auditory stimuli differently based on both the type of stimulation and the emotional content of that stimulation. This raises the possibility that music may be useful in retraining ACC function, potentially leading to more effective and targeted treatments.