Chemical and Biomolecular Engineering Research and Publications


Date of this Version



This paper was originally published in the Journal of "Angew. Chem. Int",44, 6668 –6673 ©2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Recently, hybrid structures of microorganisms with inorganic nanoscale moieties have received great interest owing to their potential in fabricating electronic systems. The electronic properties of metal nanoparticles, as a result of the singleelectron transport of current,[1] make them ideal materials for nanodevices. Concomitantly, the nanostructure of microorganisms such as bacteria,[2] viruses,[3, 4] and yeast[5] are attractive scaffolds for the templating of metal nanoparticles through the interactions of the former with surface charges and the affinity of certain metals for specific biological molecules.[2–7] However, the key challenges in building hybrid devices are 1) to pattern nanostructures without destroying the biological construct of the microorganism and 2) to achieve active integration of a biological response to the electrical transport in a nanoparticle device.