INDUCTION OF TOLERANCE BY ORAL ADMINISTRATION OF FACTOR VIII AND TREATMENT OF HEMOPHILA

Authors

Oral Alpan, Rockville, MD
Tirumalai Kamala, Rockville, MD
Polly Matzinger, Bethesda, MD
William Hugold Velander, Blacksburg, VA

Date of this Version

2011

Document Type

Article

Citation

Patent No.: US 7,867,974 B2

Comments

Appl. No.: 11/734,489

Abstract

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a Subject a therapeutically effective amount of the deficient anti gen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac atherapeutically effective amount of the appropriate clotting factor other than in a liposome, Sufficient to induce oral tolerance and Supply exogenous clotting factor to the subject.