Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine

Authors

• Ujwal R. Yanala, University of Nebraska Medical Center
• Jason M. Johanning, University of Nebraska Medical CenterFollow
• Iraklis I. Pipinos, University of Nebraska - LincolnFollow
• Robin R. High, University of Nebraska Medical CenterFollow
• Gustavo Larsen, University of Nebraska - LincolnFollow
• William H. Velander, University of Nebraska - LincolnFollow
• Mark A. Carlson, University of Nebraska Medical Center, OmahaFollow

ORCID IDs

0000-0002-8113-9199

Date of this Version

2018

Document Type

Article

Citation

PLoS ONE 13(11): e0207708

Comments

Open access

https://doi.org/10.1371/journal.pone.0207708

Abstract

Background We hypothesized that slow crystalloid resuscitation would result in less blood loss and a smaller hemoglobin decrease compared to a rapid resuscitation during uncontrolled hemorrhage.

Methods Anesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. slow, respectively, N = 12 per group; limit of 100 mL/kg). Primary endpoints were blood loss and serum hemoglobin; secondary endpoints included survival, vital signs, coagulation parameters, and blood gases.

Results The slow group had a less blood loss (1.6 vs. 2.7 L, respectively) and a higher final hemoglobin concentration (6.0 vs. 3.4 g/dL).

Conclusions Using a fixed volume of crystalloid resuscitation in this porcine model of uncontrolled intraabdominal hemorrhage, a slow IV infusion rate produced less blood loss and a smaller hemoglobin decrease compared to rapid infusion.