Fluid administration rate for uncontrolled intraabdominal hemorrhage in swine

Authors

Ujwal R. Yanala, University of Nebraska Medical Center
Jason M. Johanning, University of Nebraska Medical CenterFollow
Iraklis I. Pipinos, University of Nebraska - LincolnFollow
Robin R. High, University of Nebraska Medical CenterFollow
Gustavo Larsen, University of Nebraska - LincolnFollow
William H. Velander, University of Nebraska - LincolnFollow
Mark A. Carlson, University of Nebraska Medical Center, OmahaFollow

ORCID IDs

0000-0002-8113-9199

Date of this Version

2018

Document Type

Article

Citation

PLoS ONE 13(11): e0207708

Comments

Open access

https://doi.org/10.1371/journal.pone.0207708

Abstract

Background We hypothesized that slow crystalloid resuscitation would result in less blood loss and a smaller hemoglobin decrease compared to a rapid resuscitation during uncontrolled hemorrhage.

Methods Anesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. slow, respectively, N = 12 per group; limit of 100 mL/kg). Primary endpoints were blood loss and serum hemoglobin; secondary endpoints included survival, vital signs, coagulation parameters, and blood gases.

Results The slow group had a less blood loss (1.6 vs. 2.7 L, respectively) and a higher final hemoglobin concentration (6.0 vs. 3.4 g/dL).

Conclusions Using a fixed volume of crystalloid resuscitation in this porcine model of uncontrolled intraabdominal hemorrhage, a slow IV infusion rate produced less blood loss and a smaller hemoglobin decrease compared to rapid infusion.