Transgenic non-human mammals producing fibrinogen in their milk

William H. Velander, University of Nebraska-Lincoln

Document Type Article

The inventors of this patent are:Velander; William H. (Lincoln,NE), Drohan; William N. (Springfield, VA), Lubon; Henryk (Rockville, MD), Johnson; John L. (Blacksburg, VA) and the relevant information about this patent can be obtained from the website United States Patent No.6,984,772

Abstract

A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.