Chemical and Biomolecular Engineering Research and Publications
Date of this Version
11-2-1999
Abstract
Relating to chromatographic processes and ion-exchange and affinity matrices, a spatial installation method for a bifunctional reagent that crosslinks and/or activates a polymer matrix is disclosed, with inside-outside installation of a bifunctional reagent on and within a polymer matrix. The polymer matrix is cellulose, agarose, or chitosan particles. The installation may be followed by inside-outside ligand attachment, by further reacting the matrix with a ligand or ionic group so that a higher concentration of ligand or ionic moiety occurs on the intra-particle volume than the outer matrix surface.
Comments
The inventors of this petant are Velander; William H. (Lincoln,NE), Van Cott; Kevin E. (Lincoln, NE), Van Tassell; Roger (Blacksburg, VA) .The relevant information about this patent can be obtained from the following link of the united satates patent. United States Patent No.5,977,345