Transgenic non-human mammals producing fibrinogen in their milk

Dr. William H. Velander, University of Nebraska Lincoln

Document Type Article

The Inventors of this patent are Velander, William H. (Blacksburg, VA), Drohan, William N. (Springfield, VA), Lubon, Henryk (Rockville, MD), Johnson, John L. (Blacksburg, VA) The relevant information about this patent can be obtained from the website. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=Fibrinogen.TI.&s2=Velander. INNM.&OS=TTL/Fibrinogen+AND+IN/Velander&RS= TTL/Fibrinogen+AND+IN/Velander.html”>United States Patent No. 6,984,772

Abstract

A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glands of the animals and secreting the expressed product into a body fluid. Methodology employing such a mammal yields recombinant physiologically functional fibrinogens, subunit chain polypeptides thereof, and modified or fusion fibrinogens.