BRUSH-ARM STAR POLYMER IMAGING AGENTS AND USES THEREOF

Authors

Jeremiah A. Johnson, Boston, MA
Hung Vanthanh Nguyen, Cambridge, MA
Andrzej Rajca, Lincoln, NE

Date of this Version

2019

Citation

Pub. No.: US 2019/0038782 A1

Comments

Appl. No.: 16/024,643

Abstract

Disclosed are methods, compositions, reagents, systems, and kits to prepare nitroxide-functionalized brush-arm star polymer organic radical contrast agent (BASP-ORCA) as well as compositions and uses thereof. Various embodiments show that BASP-ORCA display unprecedented per-nitrox-ide and per-molecule transverse relaxivities for organic radical contrast agents, exceptional stability, high water solubility, low in vitro and in vivo toxicity, and long blood compartment half-life. These materials have the potential to be adopted for tumor imaging using clinical high-field ¹H MRI techniques.