αβ-PEPTIDE MIMICS OF Z-DOMAIN PEPTIDES

Authors

Samuel H. Gellman, University of WisconsinFollow
James W. Checco, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

3-15-2016

Citation

United States Patent No. US 9.284,362 B2

Comments

U.S. government work

Abstract

Described are αβ-peptide mimics of Z-domain scaffold pep tides, methods of making them, and methods of using them. The αβ-peptide mimics include B-amino acid residues and, optionally, disulfide bonds to stabilize the conformation of the mimics. The compounds may be truncated as compared to conventional Z-domain scaffold peptides and are resistant to proteolytic degradation due to the presence off-amino acid residues. The mimics can be made so as to bind selectively to a desired target.