Date of this Version
Angew Chem Int Ed Engl. 2011 September 12; 50(38): 8895–8899. doi:10.1002/anie.201103365.
Combinatorial approaches to catalysis have made an impact in targeted transformation development, including Ag-mediated carbene insertion, Sc-pybox-based asymmetric cyclopropanation, and Rh/Ir-based asymmetric hydrogenation. Useful design elements have emerged from these studies, e.g. the value of ligand self assembly, or of the inclusion of peptide-like structural elements,, in building ligand arrays. Efficient screening methods are of paramount importance for such efforts. Methods based on fluorescence, REMPI, MS, NMR, and IR thermography have appeared. A chromophore may be installed into the substrate or product of the reaction under study. Alternatively, one can exploit chromophores inherent in proteins or enzyme-associated reactions, and use these sensors to report back on product formation and composition.