Atomic force microscopy investigation of virus aggregation and assembly at chemical templates formed by scanned probe nanolithography

Authors

Chin Li Cheung, University of Nebraska at LincolnFollow
S. -W. Chung, Lawrence Livermore National Laboratory, Chemistry and Materials Science Directorate, Livermore
J. J. De Yoreo, Lawrence Livermore National Laboratory, Chemistry and Materials Science Directorate, Livermore
A. Chatterji, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA
T. Lin, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA
J. E. Johnson, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA

Date of this Version

February 2005

Comments

Published in Scanning 27:2 (2005), pp. 99–100; “Proceedings of SCANNING 2005.” Copyright © 2007 Wiley Periodicals, Inc. Used by permission. http://www3.interscience.wiley.com/journal/113412420/home

Abstract

Aggregation and assembly of macromolecules are important processes in a number of scientific fields including structural biology, medicine, and materials science. For example, growth of well-ordered two-dimensional (2-D) arrays and bulk crystals remains the rate-limiting step in macromolecular structure determination. Uncontrolled aggregation of proteins is the source of a number of devastating pathologies such as Creutzfeldt-Jakob syndrome. Moreover, the demonstrated ability of engineered viruses and proteins to act as templates for growth of inorganic nanostructures is driving a need for methods to deterministically pattern their assembly at surfaces in order to fabricate hierarchical materials and devices.