Atomic force microscopy investigation of virus aggregation and assembly at chemical templates formed by scanned probe nanolithography

Authors

• Chin Li Cheung, University of Nebraska at LincolnFollow
• S. -W. Chung, Lawrence Livermore National Laboratory, Chemistry and Materials Science Directorate, Livermore
• J. J. De Yoreo, Lawrence Livermore National Laboratory, Chemistry and Materials Science Directorate, Livermore
• A. Chatterji, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA
• T. Lin, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA
• J. E. Johnson, The Scripps Research Institute, Department of Molecular Biology, La Jolla, CA

Document Type

Article

Date of this Version

February 2005

Comments

Published in Scanning 27:2 (2005), pp. 99–100; “Proceedings of SCANNING 2005.” Copyright © 2007 Wiley Periodicals, Inc. Used by permission. http://www3.interscience.wiley.com/journal/113412420/home

Abstract

Aggregation and assembly of macromolecules are important processes in a number of scientific fields including structural biology, medicine, and materials science. For example, growth of well-ordered two-dimensional (2-D) arrays and bulk crystals remains the rate-limiting step in macromolecular structure determination. Uncontrolled aggregation of proteins is the source of a number of devastating pathologies such as Creutzfeldt-Jakob syndrome. Moreover, the demonstrated ability of engineered viruses and proteins to act as templates for growth of inorganic nanostructures is driving a need for methods to deterministically pattern their assembly at surfaces in order to fabricate hierarchical materials and devices.