Published Research - Department of Chemistry

 

Date of this Version

February 2005

Comments

Published in Scanning 27:2 (2005), pp. 99–100; “Proceedings of SCANNING 2005.” Copyright © 2007 Wiley Periodicals, Inc. Used by permission. http://www3.interscience.wiley.com/journal/113412420/home

Abstract

Aggregation and assembly of macromolecules are important processes in a number of scientific fields including structural biology, medicine, and materials science. For example, growth of well-ordered two-dimensional (2-D) arrays and bulk crystals remains the rate-limiting step in macromolecular structure determination. Uncontrolled aggregation of proteins is the source of a number of devastating pathologies such as Creutzfeldt-Jakob syndrome. Moreover, the demonstrated ability of engineered viruses and proteins to act as templates for growth of inorganic nanostructures is driving a need for methods to deterministically pattern their assembly at surfaces in order to fabricate hierarchical materials and devices.

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