Chemistry, Department of
Department of Chemistry: Dissertations, Theses, and Student Research
First Advisor
James M. Takacs
Date of this Version
Summer 7-2017
Document Type
Thesis
Citation
A thesis presented to the faculty of the Graduate College at the University of Nebraska in partial fulfillment of requirements for the degree of Master of Science
Major: Chemistry
Under the supervision of Professor James M. Takacs
Lincoln, Nebraska, July 2017
Abstract
The Rh-catalyzed, substrate directed catalytic asymmetric hydroboration of γ,δ-unsaturated amides provides a direct route to enantioenriched acyclic secondary γ-borylated carbonyl derivatives with high regio- and enantioselectivity. The catalytic condition optimization and substrate scope study is discussed, including the effects in catalytical asymmetric hydroboration on pre-installed chiral γ,δ-unsaturated amides. A mechanistic study from kinetic approach by graphical manipulation (reaction progress kinetic analysis for substrate orders and normalized time analysis for catalyst order.) was discussed in this thesis
Advisor: Professor James M. Takacs
Comments
Copyright © 2017, Shuyang Zhang. Used by permission