Published Research - Department of Chemistry

 

Date of this Version

2013

Citation

J Org Chem. 2013 January 4; 78(1): 42–47.

Comments

Copyright © 2012 American Chemical Society

Abstract

Several variants of reductive ozonolysis, defined here as the in situ generation of aldehydes or ketones during ozonolytic cleavage of alkenes, are demonstrated to work effectively in tandem with a number of C-C bond-forming reactions. For reactions involving basic nucleophiles (1,2- addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed Aldol reactions of lithium enolates) the one-pot process offers a rapid and high-yielding alternative to traditional two-step protocols.

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