Linear, redox modified DNA probes as electrochemical DNA sensors

Authors

Francesco Ricci, University of California, Santa Barbara, California
Rebecca Lai, University of Nebraska - LincolnFollow
Kevin W. Plaxco, University of California, Santa Barbara, California

Date of this Version

July 2007

Comments

Published in Chemical Communications (2007), no. 36, pp. 3768–3770; doi 10.1039/b708882e Copyright © 2007 The Royal Society of Chemistry. Used by permission. http://www.rsc.org/chemcomm

Abstract

We show here that hybridization-linked changes in the dynamics of a redox-modified, electrode-bound linear (as opposed to stem-loop) probe DNA produce large changes in Faradaic current, allowing for the ready detection of target oligonucleotides.