Synthesis and Reduction Kinetics of Sterically Shielded Pyrrolidine Nitroxides

Authors

Joseph T. Paletta, University of Nebraska-Lincoln
Maren Pink, Indiana University
Bridget Foley, University of Nebraska-Lincoln
Suchada Rajca, University of Nebraska-LincolnFollow
Andrzej Rajca, University of Nebraska - LincolnFollow

Date of this Version

2013

Citation

Org Lett. 2012 October 19; 14(20): 5322–5325.

Comments

Copyright 2013 Paletta et al.

Abstract

A series of sterically shielded pyrrolidine nitroxides were synthesized and their reduction by ascorbate (vitamin C) indicate that nitroxide 3 – a tetraethyl derivative of 3-carboxy-PROXYL – is reduced at the slowest rate among known nitroxides, i.e., at a 60-fold slower rate than that for 3- carboxy-PROXYL.