Synthesis and Reduction Kinetics of Sterically Shielded Pyrrolidine Nitroxides

Authors

• Joseph T. Paletta, University of Nebraska-Lincoln
• Maren Pink, Indiana University
• Bridget Foley, University of Nebraska-Lincoln
• Suchada Rajca, University of Nebraska-LincolnFollow
• Andrzej Rajca, University of Nebraska - LincolnFollow

Document Type

Article

Date of this Version

2013

Citation

Org Lett. 2012 October 19; 14(20): 5322–5325.

Comments

Copyright 2013 Paletta et al.

Abstract

A series of sterically shielded pyrrolidine nitroxides were synthesized and their reduction by ascorbate (vitamin C) indicate that nitroxide 3 – a tetraethyl derivative of 3-carboxy-PROXYL – is reduced at the slowest rate among known nitroxides, i.e., at a 60-fold slower rate than that for 3- carboxy-PROXYL.