Organic Radical Contrast Agents for Magnetic Resonance Imaging

Authors

• Andrzej Rajca, University of Nebraska - LincolnFollow
• Ying Wang, University of Nebraska-Lincoln
• Michael Boska, University of Nebraska Medical Center
• Joseph T. Paletta, University of Nebraska-Lincoln
• Arnon Olankitwanit, University of Nebraska - LincolnFollow
• Michael A. Swanson, University of Denver
• Deborah G. Mitchell, University of Denver
• Sandra S. Eaton, University of Denver
• Gareth R. Eaton, University of Denver
• Suchada Rajca, University of Nebraska-LincolnFollow

Document Type

Article

Date of this Version

2012

Citation

J Am Chem Soc. 2012 September 26; 134(38): 15724–15727.

Comments

Copyright 2012 Am Chemical Soc. Used by permission.

Abstract

We report a molecular design that provides an intravenously injectable organic radical contrast

agent (ORCA) that has molecular r₁ ≈ 5 mM⁻¹s⁻¹. The ORCA is based on spirocyclohexyl

nitroxide radicals and polyethylene glycol chains conjugated to a generation 4 polypropylenimine

dendrimers scaffold. The metal-free ORCA has a long shelf-life and provides selectively enhanced

MRI in mice for over 1 h.