Animal Science Department


Date of this Version

January 2004


Published in 2004 Nebraska Swine Report, compiled by Duane Reese; University of Nebraska Cooperative Extension EC 04-219-A. Prepared by the staff in Animal Science and cooperating Departments for use in Extension, Teaching and Research programs. Cooperative Extension Division, Agricultural Research Division, Institute of Agriculture and Natural Resources, University of Nebraska–Lincoln.


Sixteen sows were randomly assigned to two treatments: CON: Control corn-soybean meal diet; GLN: Cornsoybean meal diet + 2.5% crystalline glutamine. No differences (P > 0.10) between treatments were observed for sow weight loss, sow feed intake, or litter weight gain. Sow plasma glutamine concentration tended to be increased on days 7 and 21 (P < 0.13) in sows fed GLN. Milk glutamine concentration was increased (P < 0.08) on days 7 and 21 of lactation. However, suckling pig plasma glutamine concentration was not altered (P > 0.38) on day 21 by glutamine enriched milk consumption. On day 21, pigs were weaned to a common starter diet, sow treatment structure was maintained, and two additional treatments were imposed on weanling pigs and arranged in a 2 x 2 factorial: SAL: Saline injection on days 1 and 3; Lipopolysacharride (LPS ) 91 μg • lb BW-1 injection on days 1 and 3. Lipoplysacharride injection on days 1 and 3 reduced (P < 0.05) ADG during days 0 to 3, 3 to 7, and 7 to 14. Daily feed intake was reduced (P < 0.005) during days 0 to 3, 3 to 7, 7 to 14, and 14 to 21 by LPS injection. However, LPS increased ADG/ADFI during days 3 to 7 (P < 0.0001) and days 7 to 14 (P < 0.02). Progeny of sows fed CON diet gained 0.14 lb/d (P < 0.03) more weight during days 3 to 7, and consumed 0.33 lb/d more feed (P < 0.09) during days 7 to 14 versus progeny of GLN-fed sows. Small intestine length measured on day 3 was not affected (P > 0.23) by sow diet or injection type. Pigs injected with LPS had reduced (P < 0.01) small intestine empty weight. Progeny from sows that consumed CON had 10% greater empty weight on day 7 compared to progeny from sows fed GLN. Pigs injected with LPS had reduced (P < 0.01) small intestine weights on day 7 compared to pigs injected with SAL. Lipopolysacharride challenge reduced (P < 0.01) duodenum villus height. However, progeny of sows that consumed GLN had 12% greater (P < 0.05) villus height on day 3 compared to progeny of sows fed CON. Duodenum villus height on day 7 was similar in progeny from sows fed GLN and injected with SAL; whereas, progeny from sows fed GLN injected with SAL had reduced villus height (Diet × LPS, P < 0.05). Collectively, these data suggest that dietary glutamine increases sow milk glutamine concentration, but does not positively influence progeny growth performance during lactation or immediately following weaning during an immune challenge.