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THE EFFECT OF TOLBUTAMIDE ON INSULIN-COMPLEXES IN VIVO
Abstract
Although the hypoglycemic action of certain sulfon- amides was first reported in France in 1942, much remains to be learned of the mechanisms involved. That the acute effect of the sulfonylureas, particularly that of tolbutamide, might be due to direct stimulation of pancreatic beta cells was first suggested by Loubatieres (79). This theory received additional support from the work of Creutzfeldt and Soeling (35), Yalow and Berson (146), and Antoniades (3). Definitive proof seemed to be provided by the histochemical studies of Lazarus and Volk (75), who demonstrated that the beta cells show the same type of degranulation when stimulated by tolbutamide as after stimulation by hyperglycemia.
Subject Area
Pharmacology
Recommended Citation
CZERWINSKI, ANN ELIZABETH LANGLEY, "THE EFFECT OF TOLBUTAMIDE ON INSULIN-COMPLEXES IN VIVO" (1967). ETD collection for University of Nebraska-Lincoln. AAI6710658.
https://digitalcommons.unl.edu/dissertations/AAI6710658