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THE PURIFICATION AND CHARACTERIZATION OF PHENYLALANINE HYDROXYLASE
Abstract
Phenylketonuria is an inborn error of metabolism which usually results in severe mental retardation if untreated. Although neither a cure for phenylketonuria nor an adequate explanation of the associated mental retardation has been found, the retardation can be lessened considerably by restriction of the dietary intake of phenylalanine. Since the treated phenylketonuric children can be expected to produce children of their own, the metabolic defect must be studied in order that members of the new generations may grow and live productive lives.That phenylketonuria represents a defect in metabolism of phenylalanine associated with decreased activity of phenylalanine hydroxylase is a matter of common agreement. Beyond this point, however, there is little agreement concerning either the nature of the enzyme or the methods used in its preparation and purification. It was to provide new information concerning the nature of phenylalanine hydroxylase and to find new methods of preparation and purification that this study was undertaken.
Subject Area
Biochemistry
Recommended Citation
SULLIVAN, DANIEL MAURICE, "THE PURIFICATION AND CHARACTERIZATION OF PHENYLALANINE HYDROXYLASE" (1972). ETD collection for University of Nebraska-Lincoln. AAI7227431.
https://digitalcommons.unl.edu/dissertations/AAI7227431