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MANGANESE AND LIPID METABOLISM AS AFFECTED BY DIETARY MANGANESE AND FAT
Abstract
Three studies were conducted to investigate the effects of dietary manganese and fat on manganese and lipid metabolism. In Study I, 80 male, weanling rats were fed two levels of dietary fat (5% and 25%). Serum, liver and brain lipid concentrations, body weight change and fecal fat excretions were greater in rats fed the diet with 25% fat. Within each level of fat, total liver lipids decreased and liver cholesterol increased as level of dietary manganese increased. Serum cholesterol levels were highest when manganese was fed at 50 and 500 mg/kg diet. Manganese intake, fecal manganese excretion and whole blood manganese increased as level of dietary manganese increased. Dietary treatments had no effect on liver manganese concentrations. In Study II, young adult human subjects were fed two laboratory-controlled diets containing either 30% of total calories from fat (approx. 100 mg cholesterol; 10:10:10 PUFA to MUFA to SFA ratio) or 40% of total calories from fat (approx. 600 mg cholesterol; 4:14:14 fatty acid ratio). Two levels of manganese were fed (5 and 45 mg Mn/day) within each level of fat. The higher level of dietary fat generally increased fecal excretion of manganese and increased serum lipids. Dietary supplementation with 40 mg of manganese increased both fecal excretion and whole blood concentration of the mineral but had no effect on serum lipids or fecal fat. In Study III, manganese and cholesterol intakes were retrospectively calculated from the self-recorded intakes of 167 young adult human subjects categorized according to race/nationality and/or sex. Manganese intakes were negatively correlated with cholesterol intakes although this was only significant (P < 0.05) for the male subject group. No relationship was found between manganese intake and serum cholesterol levels. Cholesterol intakes were positively correlated with serum cholesterol in males and in the mixed sex Asian (Oriental) group.
Subject Area
Nutrition
Recommended Citation
JOHNSON, JAN MARIE, "MANGANESE AND LIPID METABOLISM AS AFFECTED BY DIETARY MANGANESE AND FAT" (1986). ETD collection for University of Nebraska-Lincoln. AAI8706237.
https://digitalcommons.unl.edu/dissertations/AAI8706237