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The effect of two levels of dietary manganese on the neonate
Abstract
Three studies were conducted to investigate the effects of low and high dietary manganese (Mn) on pig and human neonates. Study I: 18 sows were divided into two groups and fed diets containing 5 ppm or 20 ppm Mn during gestation. Following farrowing, sow milk Mn concentration was significantly different between groups (P $<$ 0.02) and increased in concentration with time (P $<$ 0.015). Growth and manganese concentrations (liver, kidney, heart and brain) of baby pigs from both groups were similar but Mn concentrations increased with time in the tissues evaluated (P $<$ 0.04). Baby pig blood Mn concentrations were three to four times higher than sow blood with group and time differences being significant. Femur Mn concentrations and bone breaking strength in baby pigs from the high Mn sows were greater at birth than were those from the low Mn sows but a reversal in these com-parisons occurred by day 7. The anterior/posterior femur wall thickness became thinner in the high Mn group by day 7. Study II: 12 breast-fed and 10 formula-fed infants were homogeneous in birth weight and volume of intake during the first two weeks of life. Mn intake and excretion were approximately double in the formula fed infants compared to the breast fed infants (P $<$ 0.002). All neonates were in negative manganese balance. Study III: the average estimated Mn intake for 23 women during their third trimester was 1.6 mg/da. Only 13% exceeded the Estimated Safe and Adequate Daily Dietary Intake of 2.0 mg/da and 43% consumed less than the calculated minimum Mn requirements (0.0146 mg/kg/da). Allowing for a 120% greater Mn intake than the estimated manganese intake, 30% still consumed less than the ESADDI. Tissue analysis indicated that, 13% had below normal Mn blood values; 35% had low fecal Mn content indicative of increased retention and 30% were estimated to be in negative Mn balance. There was an inverse relationship between maternal blood Mn and milk Mn (P $<$ 0.01).
Subject Area
Nutrition|Obstetrics|Gynecology|Livestock
Recommended Citation
Bell, Lynn Rae Zenner, "The effect of two levels of dietary manganese on the neonate" (1993). ETD collection for University of Nebraska-Lincoln. AAI9406074.
https://digitalcommons.unl.edu/dissertations/AAI9406074