Building the genomic base-layer of the oral “omic” world

Authors

The Forsyth Metagenomic Support Consortium, The Forsyth Metagenomic Support Consortium
Jacques Izard, The Forsyth InstituteFollow

Date of this Version

2010

Citation

Published in Interface Oral Health Science 2009: Proceedings of the 3rd International Symposium for Interface Oral Health Science, Held in Sendai, Japan, Between January 15 and 16, 2009 and the 1st Tohoku-Forsyth Symposium, Held in Boston, MA, USA, Between March 10 and 11, 2009. Editors: Takashi Sasano & Osamu Suzuki, editors.

DOI 10.1007/978-4-431-99644-6_112

Comments

Copyright © 2010 Springer-Verlag Tokyo. Used by permission.

Abstract

With the shift of molecular technologies directed toward the understanding of greater biological complexity of the oral cavity, a knowledge gap was created by the lack of genomic data from the diverse oral microorganisms. To facilitate and enable the interpretation of metagenomic, transcriptomic, and proteomic data generated or soon to be generated from oral biofilms, we are providing reference genomic information from phylogenetically diverse oral bacterial isolates. This work, initiated by the National Institute of Dental and Craniofacial Research as an isolated effort, is now part of the Human Microbiome Project. The goal of this effort is the public release of genomic data in support of functional and phylogenetic analyses of the complex oral microbiome. The genomic information acquired will be a key component in understanding the interaction of the oral biofilms with the human host and in developing novel healthcare strategies to prevent and treat oral diseases.