Toxicokinetics and Coagulopathy Threshold of the Rodenticide Diphacinone in Eastern Screech-Owls (Megascops asio)

Authors

Barnett A. Rattner, US Geological SurveyFollow
Katherine E. Horak, USDA/APHIS/WS National Wildlife Research CenterFollow
Rebecca S. Lazarus, US Geological Survey
David A. Goldade, USDA National Wildlife Research Center
John J. Johnston, Food Safety and Inspection Service, US Department of AgricultureFollow

Document Type

Article

Date of this Version

2014

Citation

Rattner, B.A., K.E. Horak, R.S. Lazarus, D.A. Goldade, and J.J. Johnston. 2014.Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in Eastern screech-owls (Megascops asio). Environmental Toxicology and Chemistry 33(1): 74-81. doi: 10.1002/etc.2390.

Comments

US government work

Abstract

In the United States, new regulations on second-generation anticoagulant rodenticides will likely be offset by expanded use of first-generation anticoagulant rodenticides. In the present study, eastern screech-owls (Megascops asio) were fed 10 mg diphacinone/g wet weight food for 7 d, and recovery was monitored over a 21-d postexposure period. By day 3 of exposure, diphacinone (DPN) was detected in liver (1.63 mg/g wet wt) and kidney (5.83 mg/g) and coagulopathy was apparent. By day 7, prothrombin time (PT) and Russell’s viper venom time (RVVT) were prolonged, and some individuals were anemic. Upon termination of exposure, coagulopathy and anemia were resolved within 4 d, and residues decreased to