Absorption, Distribution, and Excretion of [¹⁴C]-3-Chloro-4 methylaniline Hydrochloride in Two Species of Birds Following a Single Oral Dose

Authors

• David A. Goldade, National Wildlife Research Center
• John D. Tessari, Colorado State University
• John J. Johnston, National Wildlife Research CenterFollow

Document Type

Article

Date of this Version

November 2004

Comments

Published by J. Agric. Food Chem. 2004, 52, 8074-8080.

Abstract

Ring-labeled [¹⁴C]-3-chloro-4-methylaniline hydrochloride (250 μg per bird) was delivered to 21 red-winged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and excretion of radioactivity were determined at 15 and 30 min and 1, 4, 8, 12, and 24 h (n = 3 per time point). Direct measurement of radioactivity as well as measurement following combustion was accomplished using a liquid scintillation counter. Elimination from most tissues followed a two-compartment model, with very rapid elimination occurring between time 0 and 4 h and a much slower elimination phase occurring after that. The average half-life of elimination for the initial phase in most tissues examined was 0.16 h for juncos and 0.62 h for blackbirds. The average for the slower second phase of elimination was 3.4 h for juncos and 5.4 h for blackbirds. The radioactivity in blackbird kidney tissues did not change significantly for the duration of the test, pointing toward the kidney as a possible site of action for this important agricultural chemical.