Quantification of plasma and egg 4,4′ dinitrocarbanilide (DNC) residues for the efficient development of a nicarbazin-based contraceptive for pest waterfowl

Authors

John J. Johnston, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research CenterFollow
Walter M. Britton, University of Georgia, Athens, GA
Alexander MacDonald, Pharma Science Inc.
Thomas M. Primus, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center
Margaret J. Goodall, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center
Christi A. Yoder, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center
Lowell A. Miller, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research CenterFollow
Kathleen A. Fagerstone, United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center

Document Type

Article

Date of this Version

December 2001

Comments

Published in Pest Manag Sci 58:197-202 (online: 2001).

Abstract

Urbanization and associated landscaping has increased the abundance of year-round habitat for waterfowl, resulting in vegetation damage, loss of recreational activities, air transportation mishaps and health hazards. As part of a research program to develop socially acceptable techniques for management of pest bird populations, we are evaluating nicarbazin as a contraceptive in pest and surrogate avian species. As reproductive studies with Canada Geese (Branta canadensis) are tedious due to the difficulty of conducting controlled field studies and/or breeding geese in captivity, we evaluated the effects of oral nicarbazin administration on the production and hatchability of chicken studies are being conducted with geese to determine the diet nicarbazin concentration required to produce the desired blood and plasma DNC concentrations. This approach permits the expeditious evaluation of formulations and dosing regimes by simply monitoring blood DNC concentrations in target species.