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This study aims to identify the factors of Challenges and problems of Library and Information Science Research from the perspective of field specialists in Iran .This study examines one of these experiences to explanation conditions and strategies necessary for the success of such experience. This research, on the other hand has tried to clarify factors that affect on research .The method of the study is grounded theory. The survey was adopted for data collection through Deep and semi-structured interviews were conducted to collect information with 13 knowledge and science experts selected by mixed or mixed purpose sampling. After three steps of coding (Strauss & Corbin, 1998), the central phenomenon of the study was identified: " Research pathology in knowledge and information science” . Then paradigmatic model was developed. The results show that Human challenges ,Lack of time management, Financial crisis ,Lack of research popularity, Weak research structure, Lack of commitment ,Problem making ,Duplication, Lack of strategic planning are the most important affecting the phenomenon. four main outcome of this phenomenon is Implementation,Nativism ,Empowering information consultation and Research empowerment.