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The study carried out an analysis of entrepreneurship courses of library and information science education in South-East Geo-political zone of Nigeria, the LIS schools in South-East Nigeria where LIS entrepreneurship courses are available and taught. These LIS business related courses are intended to equip LIS students with the necessary skills to be job and wealth creators upon graduation. The population comprised of 300 and 400 level students of library and information science students from five LIS schools in South-East Nigeria and a total of 1041 copies of questionnaire were distributes with a return rate of 735. Data collected were analysed using bar chart, tables and percentages. Findings from the study revealed the different entrepreneurial courses available and taught by LIS schools in South East Geo-political Zone to LIS undergraduates for job creation and self-reliant. However, LIS curriculum should be that which ensures equality and uniformity especially in its business related courses with the resultant effect of having Nigerian graduates who can confidently, creatively and innovatively contribute to the economic development of Nigeria. It was also recommended that Stakeholders in the educational sector, National Association of Library and Information Science Educators (NALISE) and Heads of LIS Departments to create forum where curriculum for LIS entrepreneurship education are harmonized for maximum and holistic achievement of the objectives.